7 Common and Serious Side Effects of Airsupra
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Medically reviewed by Oghenefejiro Okifo | MD, Harvard Medical School | Henry Ford Hospital - Detroit, MI on November 2nd, 2023.
The condition occurs when ascending above 8,000 feet too rapidly, as oxygen levels drop to 75% of sea level at this elevation, overwhelming the body's ability to adapt.
Symptoms typically emerge 6-24 hours after arrival and progress from mild headache and nausea to potentially fatal cerebral edema (HACE) or pulmonary edema (HAPE) within 24-72 hours if untreated.
Physical fitness provides no protection—even Olympic athletes can develop severe cases, while some individuals have genetic variations that make them more susceptible regardless of conditioning.
The "climb high, sleep low" rule is critical: ascend no more than 1,000-1,600 feet in sleeping elevation per day once above 10,000 feet, with rest days every 3,000 feet of gain.
Acetazolamide (Diamox) 125-250mg twice daily starting 1-2 days before ascent can reduce symptoms by 75%, though it may cause tingling fingers and altered taste.
When traveling to higher elevations, it's important to be aware of altitude sickness, also known as mountain sickness. This condition can affect anyone, regardless of age or fitness level, and can cause a range of symptoms. In this article, we'll explore what causes altitude sickness, the different types, symptoms to watch out for, and how to prevent it.
Altitude sickness occurs when you travel to a higher elevation too quickly. As you go up, the air pressure drops, and there is less oxygen available. Your body needs time to adjust to this change in pressure. If you live at a moderately high altitude, your body is already accustomed to the air pressure. However, if you travel to a place at a higher altitude than you're used to, you may experience altitude sickness.
There are three levels of altitude sickness:
Acute Mountain Sickness (AMS): This is the mildest form and is very common. Symptoms can feel like a hangover and include dizziness, headache, muscle aches, and nausea.
High-Altitude Pulmonary Edema (HAPE): This is a buildup of fluid in the lungs that can be very dangerous and even life-threatening. It is the most common cause of death from altitude sickness.
High-Altitude Cerebral Edema (HACE): This is the most severe form of altitude sickness and happens when there's fluid in the brain. It is also life-threatening, and immediate medical attention is necessary.
Common symptoms of altitude sickness include:
Headache
Dizziness
Nausea and vomiting
Fatigue and loss of energy
Shortness of breath
Sleep problems
Loss of appetite
Symptoms usually appear within 12 to 24 hours of reaching a higher elevation and improve within a day or two as your body adjusts. However, if you have a more moderate case, symptoms may feel more intense and not improve with over-the-counter medications. You may experience worsening shortness of breath, fatigue, loss of coordination, and trouble walking.
In severe cases of HAPE or HACE, additional symptoms may include:
Confusion
Shortness of breath even at rest
Inability to walk
A cough that produces a white or pink frothy substance
Coma
Anyone can develop altitude sickness, even Olympic athletes. Factors that may increase your risk include:
Rapid ascent to higher elevations
High altitude of the destination
Sleeping at a high altitude
Physical activity at a high elevation
Age (young people are more susceptible)
Previous history of altitude sickness
Certain medical conditions, such as diabetes or lung disease, do not automatically increase your risk. However, people with sickle cell anemia, COPD, unstable angina, high-risk pregnancy, heart failure, cystic fibrosis, or recent heart attacks or strokes may have difficulty tolerating the change in altitude.
If you experience a headache and at least one other symptom of altitude sickness within a day or two of changing elevation, you may have altitude sickness. For mild symptoms, rest at your current altitude to see if your body adjusts. Stay warm, drink plenty of fluids, and avoid going any higher until your symptoms resolve.
If your symptoms are severe or do not improve after a couple of days, descend to a lower elevation as quickly as possible. Avoid exertion and seek medical help. Your doctor may perform a chest examination, X-ray, MRI, or CT scan to check for fluid in your lungs or brain. Treatment for HACE may include the steroid dexamethasone, while HAPE requires supplemental oxygen and possibly medications, in addition to moving to a lower altitude.
The best way to prevent altitude sickness is through acclimatization, which allows your body to gradually adjust to the changes in air pressure. Some tips for acclimatization include:
Start your journey below 10,000 feet
If flying or driving to a higher elevation, stop at a lower destination for at least a full day before going higher
If walking, hiking, or climbing above 10,000 feet, only ascend an additional 1,000 feet per day
Talk to your doctor about whether medications like acetazolamide are right for you to prevent altitude sickness
Rest for at least a day for every 3,000 feet of elevation gain
Climb high and sleep low: If climbing over 1,000 feet in a day, descend to a lower altitude to sleep
Drink 3-4 quarts of water daily and ensure about 70% of your calories come from carbohydrates
Avoid tobacco, alcohol, and medications like sleeping pills for the first 48 hours
Limit vigorous exercise for the first 48 hours
Learn to identify the early signs of altitude sickness and descend to a lower elevation if symptoms appear
By understanding the causes, symptoms, and prevention strategies for altitude sickness, you can better prepare for your high-altitude adventures. Remember to listen to your body, take necessary precautions, and seek medical attention if symptoms worsen or persist. With proper planning and acclimatization, you can safely enjoy the beauty of high-elevation destinations.
For more information on altitude sickness, visit:
Prevention through gradual ascent is far more effective than treatment, as descent is often the only cure for severe cases. Recognition of early warning signs—persistent headache unrelieved by rest and pain medication—can prevent life-threatening complications. If you're planning high-altitude travel or experiencing concerning symptoms, Doctronic can provide personalized guidance on prevention strategies and when to seek immediate care.
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